|
| Status |
Public on Mar 09, 2016 |
| Title |
Whole Blood long non-coding RNA and mRNA Expression Profiles in Humans Exposed to Multi-walled Carbon Nanotubes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
|
| Summary |
As the application of carbon nanotubes (CNT) in consumer products continues to rise, studies have expanded to determine the associated risks of exposure on human and environmental health. In particular, several lines of evidence indicate that exposure to multi-walled carbon nanotubes (MWCNT) could pose a carcinogenic risk similar to asbestos fibers. However, to date the potential markers of MWCNT exposure are not yet explored in humans.
|
| |
|
| Overall design |
Global mRNA and lncRNA expression profiles in the whole blood of exposed workers, having direct contact with MWCNT aerosols for atleast 6 months (n=8), were compared with expression profiles of non-exposed (n=7) workers (e.g., proffessional and/or technical staff) from the same manufacturing facility.
|
| |
|
| Contributor(s) |
Yanamala N, Fatkhutdinova L, Shvedova AA |
| Citation(s) |
26930275, 26902652 |
| Submission date |
Oct 07, 2015 |
| Last update date |
Mar 16, 2020 |
| Contact name |
Anna A Shvedova |
| E-mail(s) |
ats1@cdc.gov
|
| Organization name |
CDC/NIOSH
|
| Department |
HELD
|
| Lab |
EAB
|
| Street address |
1095 willowdale Rd
|
| City |
morgantown |
| State/province |
WV |
| ZIP/Postal code |
26508 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16956 |
Agilent-045997 Arraystar human lncRNA microarray V3 (Probe Name Version) |
|
| Samples (15)
|
|
| Relations |
| BioProject |
PRJNA298079 |
Less...
More...