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Series GSE7410 Query DataSets for GSE7410
Status Public on Mar 01, 2008
Title Gene expression in early stage cervical cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Gene expression profiling of early stage cervical cancer tumours with and without lymph node metastasis, in order to predict lymph node metastasis before treatment.
Subsequently, comparing gene expression profiles between healthy cervical tissue and early stage cervical cancer tissue.
Keywords: Disease stage analysis
 
Overall design All patients had clinical FIGO stage IB-IIA cervical cancer, the low-risk group (N) included 19 patients without unfavourable prognostic factors (positive lymph nodes, parametrial invasion, positive margins or a combination of unfavourable prognostic factors); the high risk group (P) consisted of 16 patients with lymph node metastasis, who were treated with adjuvant radiation therapy with or without chemotherapy. Healthy cervical tissue biopsies (H) were collected from 5 non-cervical carcinoma patients who underwent hysterectomy for benign reasons. RNA pooled from all tumour tissue samples was used as reference sample. Log-ratios of five technical replicates were used for normalization.
 
Contributor(s) Biewenga P, Ver Loren van Themaat E
Citation(s) 18191186
Submission date Mar 30, 2007
Last update date Dec 06, 2012
Contact name Petra Biewenga
Organization name Academic Medical Centre
Department Department Gynaecologic Oncology
Street address Meibergdreef 9
City Amsterdam
ZIP/Postal code 1100DD
Country Netherlands
 
Platforms (1)
GPL1708 Agilent-012391 Whole Human Genome Oligo Microarray G4112A (Feature Number version)
Samples (45)
GSM178828 Early stage cervical tumour without lymph node metastasis 1
GSM178829 Early stage cervical tumour without lymph node metastasis 2
GSM178830 Early stage cervical tumour without lymph node metastasis 3
Relations
BioProject PRJNA100379

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE7410_RAW.tar 468.6 Mb (http)(custom) TAR (of TXT)

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