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Series GSE7424 Query DataSets for GSE7424
Status Public on Apr 03, 2007
Title Intragraft gene expression profile associated with the induction of tolerance
Organism Mus musculus
Experiment type Expression profiling by array
Summary Xenotransplantation holds the promise of providing an unlimited supply of donor organs for terminal patients with organ failure. The gal carbohydrate results in rejection of wild type pig grafts, however, chimerism established by expression of the GalT gene prior to transplantation in GalT knockout mice results in tolerance to Gal+ heart grafts.
We used microarrays in order to further understand the early events that occur within grafts that demonstrate tolerance.
Keywords: transplntation tolerance
Overall design The GalT BMT recipient is a GalT knockout mouse which recieved GalT gene transduced allo-bone marrow cells transplantation after sublethal irradiation. A heart of wild type C57BL/6 was heterotopically transplanted into the recipient after GalT BMT. Syngeneic Control recipient is a wild type C57BL/6 transplanted a heart of wild C57BL/6.
Contributor(s) Doki T, Kearns-Jonker M
Citation(s) 18267024
Submission date Apr 02, 2007
Last update date Feb 11, 2019
Contact name Tomoko Doki
Phone 323-669-5652
Fax 323-662-1709
Organization name Childrens Hospital Los Angeles
Department Cardiothoracic Surgery Research
Lab Transplantation Biological Research Laboratory
Street address 4661 Sunset Blvd.
City Los Angeles
State/province CA
ZIP/Postal code 90027
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (8)
GSM179573 heartgraft_GalTBMT_early_rep1.
GSM179574 heartgraft_GalTBMT_early_rep2.
GSM179575 heartgraft_GalTBMT_early_rep3.
BioProject PRJNA97859

Download family Format
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Supplementary file Size Download File type/resource
GSE7424_RAW.tar 29.9 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data provided as supplementary file

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