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| Status |
Public on Oct 31, 2016 |
| Title |
The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
In this study we investigated changes in gene expression induced by 2cPE (a non-selective isopeptidase inhibitor) in leukemia cells isolated from 10 different patients suffering of B-cell chronic lymphocytic leukemia. We compared 2cPE induced changes in mRNA levels with those induced by bortezomib, another well characterized proteasome inhibitor. Both inhibitors trigger apoptosis in leukemia cells.
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| Overall design |
Gene expression profiles of B-CLL cells coming from several patients treated with the UPS inhibitors bortezomib and 2cPE are compared to the profiles of untreated cells.
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| Contributor(s) |
Tomasella A, Picco R, Agorbissa A, Bianchi E, Manfredini R, Benedetti F, Valentina T, Frezzato F, Trentin L, Sememzato G, Delia D, Brancolini C |
| Citation(s) |
27259251 |
| Submission date |
Oct 30, 2015 |
| Last update date |
Jan 30, 2017 |
| Contact name |
raffaella picco |
| E-mail(s) |
raf.picco@uniud.it
|
| Organization name |
university of Udine
|
| Department |
department of medical and biological sciences
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| Lab |
bioinformatics
|
| Street address |
piazzale kolbe 4
|
| City |
udine |
| ZIP/Postal code |
33100 |
| Country |
Italy |
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| Platforms (1) |
| GPL20650 |
[HG-U219_Hs_ENTREZG_18] Affymetrix Human Genome U219 Array [CDF: Brainarray HGU219_Hs_ENTREZG_v18] |
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| Samples (26)
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| Relations |
| BioProject |
PRJNA300624 |
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