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| Status |
Public on Nov 05, 2015 |
| Title |
Gene Expression Profiling of IL-17A-treated Synovial Fibroblasts from the Human Temporomandibular Joint |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Synovial fibroblasts contribute to the inflammatory temporomandibular joint under pathogenic stimuli. Synovial fibroblasts and T cells participate in the perpetuation of joint inflammation in a mutual activation feedback, via secretion of cytokines and chemokines that stimulate each other. IL-17 is an inflammatory cytokine produced primarily by Th17 cells that plays critical roles in the pathogenesis of numerous autoimmune and inflammatory diseases. Here, we investigated the roles of IL-17A in temporomandibular joint disorders (TMD) by using genome-wide analysis of synovial fibroblasts isolated from patients with TMD. We analyzed the gene expression profiles of synovial fibroblasts that were treated with or without IL-17A.
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| Overall design |
IL-17 induced gene expression in synovial fibroblasts from human temporomandibular joint was measured at 4 hours after treated with IL-17A (10 ng/ml) and untreated control samples. This experiment used one donor sample.
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| Contributor(s) |
Hattori T, Ogura N, Akutsu M, Kawashima M, Watanabe S, Ito K, Kondoh T |
| Citation(s) |
26839464 |
| Submission date |
Nov 04, 2015 |
| Last update date |
Jan 09, 2018 |
| Contact name |
Toshio Hattori |
| E-mail(s) |
t.hattori.dentistry@gmail.com
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| Phone |
+81-47-360-9395
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| Organization name |
Nihon University School of Dentistry at Matsudo
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| Department |
Maxillofacial Surgery
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| Street address |
2-870-1, Sakaecho-Nishi, Matsudo
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| City |
Chiba |
| ZIP/Postal code |
271-8587 |
| Country |
Japan |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA301133 |
