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Series GSE75092 Query DataSets for GSE75092
Status Public on Jul 31, 2017
Title The long noncoding RNA expression profiles of paroxysmal atrial fibrillation identified by microarray analysis
Organism Homo sapiens
Experiment type Expression profiling by array
Non-coding RNA profiling by array
Summary The purpose of the present study was to identify aberrantly expressed lncRNAs in pAF and predict their potential functions. We recruited three pAF patients undergoing radiofrequency catheter ablation into our study. Peripheral blood leukocytes (PBL) and coronary sinus blood leukocytes (CSBL) were harvested from pAF patients at the same time during the operation. LncRNAs and mRNAs profiles in leukocytes were detected by microarray between pAF patients and controls. We identified 2095 lncRNAs and 1584 mRNAs differentially expressed between pAF patients and controls. Furthermore, expressions of lncRNAs and mRNAs in leukocytes were also measured between peripheral blood (PB) and coronary sinus blood (CSB). The 866 lncRNAs and 528 mRNAs were shown to be aberrantly expressed between CSBL and PBL in all three pAF patients. Bioinformatic analyses (lncRNA classification and subgroup, gene ontology analysis, pathway analysis and gene co-expression network construction) were performed for differentially expressed lncRNAs and mRNAs. Lastly, we confirmed seven aberrant lncRNAs and five dysregulated mRNAs by qRT-PCR. Our results demonstrated the aberrantly expressed lncRNAs and mRNAs in pAF and these lncRNAs/mRNAs may exert a vital role in pAF biology.
 
Overall design To explore the potential involvement of lncRNAs in paroxysmal atrial fibrillation(pAF), we firstly conducted lncRNAs and mRNAs profiling in leukocytes by microarray between pAF patients and controls. Then, expressions of lncRNAs/mRNAs in leukocytes were detected between peripheral blood (PB) and coronary sinus blood (CSB) in all three pAF patients.
 
Contributor(s) Su Y, Yue Y, Yang S
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Submission date Nov 17, 2015
Last update date Mar 12, 2018
Contact name Ying Su
Organization name Capital Medical University affiliated Beijing Shijitan Hospital
Street address Tieyi Rd. No.10, Yangfangdian, Haidian district
City Beijing
ZIP/Postal code 100038
Country China
 
Platforms (1)
GPL16956 Agilent-045997 Arraystar human lncRNA microarray V3 (Probe Name Version)
Samples (9)
GSM1942514 ExVivoBlood_paroxysmal atrial fibrillation_coronary sinus blood_rep1
GSM1942515 ExVivoBlood_paroxysmal atrial fibrillation_coronary sinus blood_rep2
GSM1942516 ExVivoBlood_paroxysmal atrial fibrillation_coronary sinus blood_rep3
Relations
BioProject PRJNA302440

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GSE75092_RAW.tar 24.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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