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| Status |
Public on Feb 02, 2016 |
| Title |
Microarray data of mRNA exprssion in ERK/MAPK inactivated P14 mouse sensorimotor cortices |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Inactivation of ERK/MAPK signaling in developing postmitotic cortical excitatory neurons results in a significent loss of Ctip2 positive layer 5 neurons and axon projections. Microarray dada revealed the reduced levels of a vast majority of layer V specific transcripts.
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| Overall design |
ERK/MAPK signaling was inactivated by germline deletion of the gene Mek2 and conditional delection of the gene Mek1 using Nex:Cre driver. Sensorimotor cortices were dissected from 3 pair of mutant and control mice at the age of P14. Total RNAs were extracted using Qiagen miRNeasy kit and subjected to quality check and microarray analysis. Total 6 samples.
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| Contributor(s) |
Xing L, Snider WD, Newbern JM |
| Citation(s) |
26848828 |
| Submission date |
Nov 18, 2015 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Jason M Newbern |
| E-mail(s) |
jason.newbern@asu.edu
|
| Organization name |
Arizona State University
|
| Department |
School of Life Sciences
|
| Street address |
PO Box 874501
|
| City |
Tempe |
| State/province |
AZ |
| ZIP/Postal code |
85287-4501 |
| Country |
USA |
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| Platforms (2) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA302595 |
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