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| Status |
Public on Jan 04, 2016 |
| Title |
Comparison of expression profiles of WT and Nrf2AY/AY mutant macrophages under electrophilic stress agent [RNA-Seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Nrf2(A502Y) mutant failed to recognize cis-element required for induction of Nrf2 target genes.To examine whether Nrf2(A502Y) supports expression of a distinct gene set from that supported by Nrf2, RNA-Seq analysis was performed. We compared gene expression profiles in peritoneal macrophages from Nrf2+/+ and Nrf2AY/AY mice between basal and DEM (which is an electorophilic stress agent promoting Nrf2 induction)-treated conditions.
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| Overall design |
mRNA profiles of wild type (WT) and Nrf2AY/AY (AY) mutant macrophages under basal and DEM-treated condition were generated by deep sequencing, in triplicate.
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| Contributor(s) |
Otsuki A, Mikiko S, Katsuoka F, Tsuchida K, Suda H, Morita M, Shimizu R, Yamamoto M |
| Citation(s) |
26677805 |
| Submission date |
Nov 19, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Masayuki Yamamoto |
| E-mail(s) |
masiyamamoto@med.tohoku.ac.jp
|
| Phone |
81-22-717-8084
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| Organization name |
Tohoku University Graduate School of Medicine
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| Department |
Medical Biochemistry
|
| Street address |
2-1 Seiryo-machi, Aoba-ku
|
| City |
Sendai |
| ZIP/Postal code |
980-8575 |
| Country |
Japan |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE75177 |
Comparison of expression profiles of WT and Nrf2AY/AY mutant macrophages under electrophilic stress agent |
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| Relations |
| BioProject |
PRJNA302713 |
| SRA |
SRP066411 |
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