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Series GSE7605 Query DataSets for GSE7605
Status Public on Nov 01, 2007
Title Expression in Kir6.1-deficient heart following LPS challenge
Organism Mus musculus
Experiment type Expression profiling by array
Summary KATP opposes depolarization of cells in the heart, smooth muscle, and other tissues by permitting the efflux of potassium ions and this efflux is evidently required to prevent unopposed vasoconstriction and insufficiency of coronary artery blood flow triggered by one or more cytokines induced in response to LPS. The cytokine(s) involved must elicit a dysfunctional response in the Kir6.1-deficient environment, and to gain further insight into the effects of the mutation, we examined the transcriptional status of whole heart, isolated from normal C57BL/6J mice or KcnJ8Md/Md mice, before and after injection of 1 μg of LPS
Keywords: Time course, stress response, disease state analysis, genetic modification
Overall design 3 mice per genotype were injected with 0.5 ug LPS in PBS or with PBS alone and hearts were collected after 30 min or 3 h.
Contributor(s) Croker BA, Beutler BA
Citation(s) 18026101
Submission date Apr 24, 2007
Last update date Feb 11, 2019
Contact name Yu Xia
Phone 858-784-7364
Organization name The Scripps Research Institute
Department Genetics
Lab Bruce Beutler
Street address 10550, N. Torrey Pines Rd.
City La Jolla
State/province CA
ZIP/Postal code 92037
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (18)
GSM183971 ControlHeart_LPS_3h_rep1
GSM183972 ControlHeart_LPS_3h_rep2
GSM183973 ControlHeart_LPS_3h_rep3
BioProject PRJNA100169

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE7605_RAW.tar 106.9 Mb (http)(custom) TAR (of CEL, EXP)
Raw data provided as supplementary file
Processed data included within Sample table

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