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Series GSE76127 Query DataSets for GSE76127
Status Public on Dec 18, 2015
Title Gene expression data of canine osteosarcoma primary tumors (Affymetrix Canine 2.0 array)
Organism Canis lupus familiaris
Experiment type Expression profiling by array
Summary The recently developed COXEN method (PMID: 17666531) has been used to successfully extrapolate gene signatures of drug sensitivity across different tumor histotypes. We wanted to explore the utility of COXEN to predict chemosensitivity in canine cancer, specifically if we could extrapolate gene signatures identified in human datasets over to canine osteosarcoma tumors. This dataset of canine osteosarcoma tumor samples has available clinical outcome data after patients had infected limbs amputated and were treated with doxorubicin and/or carboplatin. We performed microarray analysis on this panel of tumor samples for validating our COXEN prediction models for doxorubicin or carboplatin sensitivity.
 
Overall design Chemotherapy naive primary tumors were collected at the time of amputation and archived at the Flint Animal Cancer Center. RNA was extracted from 33 frozen archived tumor samples, followed by microarray analysis. The gene expression data was RMA preprocessed, scaled and were used as a independent test set to evaluate developed prediction models of sensitivity to doxorubicin or carboplatin. Drug predictions were than compared to clinical outcome in these patients that received doxorubicin and/or carboplatin.
 
Contributor(s) Gustafson DL, Fowles JS
Citation(s) 26892349, 34635775
Submission date Dec 17, 2015
Last update date Nov 03, 2021
Contact name Daniel L Gustafson
E-mail(s) daniel.gustafson@colostate.edu
Organization name Colorado State University
Department Clinical Sciences
Lab Gustafson
Street address 300 West Drake Rd
City Fort Collins
State/province CO
ZIP/Postal code 80523
Country USA
 
Platforms (1)
GPL3738 [Canine_2] Affymetrix Canine Genome 2.0 Array
Samples (33)
GSM1974802 patient 208768
GSM1974803 patient 205677
GSM1974804 patient 146719
This SubSeries is part of SuperSeries:
GSE76128 Gene expression data of canine cancer cell lines and osteosarcoma primary tumors
Relations
BioProject PRJNA306371

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE76127_RAW.tar 112.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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