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Series GSE7657 Query DataSets for GSE7657
Status Public on May 01, 2008
Title Identification of phase-specific arthritis-related genes in mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Rheumatoid arthritis (RA), one of the most common polygenic diseases, is characterized by a chronic, progressive inflammation mainly in joints and has an unknown etiology. Numerous studies have revealed the significance of cytokines TNF and IL-1 in the onset and progression of RA. Due to the complexity of interactions among different cytokines and immune cells, little is known about the precise molecular mechanisms underlying RA. In this study, oligonucleotide microarray analysis and a mouse model of RA, IL-1 receptor antagonist deficient mice were used to address this issue. Two hundred and ninety transcripts were found to be dysregulated greater than or equal to 2-fold in the diseased mice. Phase-specific gene expression changes were identified, including early increase and late decrease of heat shock protein coding genes and Cyr61. Moreover, common gene expression changes were also observed, especially the upregulation of paired-Ig-like receptor A (Pira) in both early and late phases of arthritis. We conclude that common and distinct gene expression change patterns that were identified globally may represent novel opportunities for better control of RA through early diagnosis and development of alternative therapeutic strategies.
Keywords: Time course
Overall design Six wild-type and 6 Il1rn deficient BALB/c mice at 1 month and 4 month (3 for each time point) were used for microarray analysis of splenic gene expression profiling.
Contributor(s) Yan J, Jiao Y, Jiao F, Gu W, Stuart J
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Submission date Apr 27, 2007
Last update date Feb 11, 2019
Contact name Jian Yan
Phone 901-448-7830
Organization name University of Tennessee Health Science Center
Department Orthopedics Surgery
Lab Weikuan Gu
Street address 956 Court Ave
City Memphis
State/province TN
ZIP/Postal code 38163
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (12)
GSM185009 Spleen_ko_1m_rep1
GSM185010 Spleen_ko_1m_rep2
GSM185011 Spleen_ko_1m_rep3
BioProject PRJNA99753

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Supplementary file Size Download File type/resource
GSE7657_RAW.tar 41.6 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file

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