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| Status |
Public on Jun 01, 2016 |
| Title |
Myelin-allied gene expression profile of adult neural progenitors shortly after onset of differentiation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Spontaneous neural repair from endogenous neural stem cells (NSCs) occurs in response to central nervous system (CNS) injuries or diseases to only a limited extent from endogenous NSCs niches. Uncovering the mechanisms that control neural repair and can be further manipulated to promote towards oligodendrocyte progenitors cells (OPCs) and myelinating oligodendrocytes is a major objective.
Our aim was to identify myelin specific transcriptional regulators amongst large transcriptional changes shortly after differentiation of neural stem cells from the subventricular zone (SVZ) of adult mice
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| Overall design |
SVZ-NSCs from adult mice were differentiated for 12 and 24 h in absence of growth factor (bFGF, EGF) and subjected for gene array as compared with undifferentiated NSCs cultured in presence of growth factors (n=5 samples per condition).
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| Contributor(s) |
Zilkha-Falb R, Gurevich M, Hanael E, Achiron A |
| Citation(s) |
28935237 |
| Submission date |
Jan 19, 2016 |
| Last update date |
May 04, 2018 |
| Contact name |
Michael Gurevich |
| E-mail(s) |
gurevich@sheba.health.gov.il
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| Organization name |
Sheba Medical Center
|
| Department |
Multiple Sclerosis Center
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| Lab |
Neurogenomics
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| Street address |
Tel-Hashomer
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| City |
Ramat-Gan |
| ZIP/Postal code |
52621 |
| Country |
Israel |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA309158 |
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