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Series GSE7707 Query DataSets for GSE7707
Status Public on Oct 21, 2008
Title Gene expression changes in multiple brain regions of a mouse MPTP model of Parkinson's disease
Organism Mus musculus
Experiment type Expression profiling by array
Summary In Parkinson’s disease (PD), the progressive loss of substantia nigra dopamine cells has been associated with their vulnerability to oxidative stress, inflammation, and mitochondrial dysfunction. To identify multiple gene transcription alterations that may potentially underlie early stages of related degenerative processes in brain, we used the subcrhonic MPTP mouse model of PD and microarray analysis at 4 days post-MPTP when neurotoxic activity is maximal. Since PD results in gene changes throughout the brain, we assessed MPTP's effects in multiple regions: frontal cortex, striatum and midbrain.
Keywords: neurotoxic response
Overall design Mus musculus adults were randomly assigned to either MPTP or saline treatment groups. Brain regions of interest (frontal cortex, striatum and midbrain) were dissected from both groups for RNA extraction and hybridization on Affymetrix microarrays.
Contributor(s) Sforza DM, Hartenstein P, Lacan G, Melega WP, Toga AW
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Submission date May 04, 2007
Last update date Feb 11, 2019
Contact name Daniel M Sforza
Organization name George Mason University
Department Computational and Data Sciences
Street address 4400 University Drive
City Fairfax
State/province VA
ZIP/Postal code 22030
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (18)
GSM187351 frontal cortex control, biological rep1
GSM187352 frontal cortex control, biological rep2
GSM187353 frontal cortex control, biological rep3
BioProject PRJNA99841

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Supplementary file Size Download File type/resource
GSE7707_RAW.tar 63.2 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file

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