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Series GSE7762 Query DataSets for GSE7762
Status Public on Jun 14, 2007
Title Morphine effects on striatal transcriptome in four inbred mouse strains
Organism Mus musculus
Experiment type Expression profiling by array
Summary Chronic opiate use produces molecular and cellular adaptations in the nervous system, leading to tolerance, physical dependence and addiction. Genome-wide comparison of morphine-induced changes in brain transcription of mouse strains with different opioid-related phenotypes provides an opportunity to discover the relationship between gene expression and behavioral response to the drug.
Keywords: Drug response
Overall design Microarray experiment was designed to determine the impact of genetic background on the transcriptional effects of morphine in the striatum. The effects of single (20 mg/kg, s.c.) and repeated morphine administration (10-40 mg/kg, 3 times daily for 5 days) were analyzed in four inbred mouse strains (129P3/J. DBA/2J, C57BL/6J, SWR/J). Twelve experimental groups were compared. Control animals received injections of saline. Three independent biological replicates of the microarray were prepared for each experimental group. For each array, independent pools of total RNA from three animals were prepared.
Contributor(s) Korostynski M, Piechota M, Przewlocki R
Citation(s) 17598886
Submission date May 08, 2007
Last update date Feb 11, 2019
Contact name Marcin Piechota
Phone (+4812) 6623328
Organization name Institute of Pharmacology PAS
Department Molecular Neuropharmacology
Street address Smetna 12
City Krakow
ZIP/Postal code 31-343
Country Poland
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (36)
GSM187965 129P3/J SAL, Rep1
GSM187966 129P3/J SAL, Rep2
GSM187967 129P3/J SAL, Rep3
BioProject PRJNA99893

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE7762_RAW.tar 134.1 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file

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