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Series GSE7774 Query DataSets for GSE7774
Status Public on Oct 31, 2007
Title Transcriptional changes in Lhx8 Null newborn mouse ovaries
Organism Mus musculus
Experiment type Expression profiling by array
Summary Lhx8 is a homeobox gene expressed in oocytes and critical in oogenesis. Lhx8 deficiency leads to rapid loss of postnatal oocytes. Early oocyte differentiation is poorly understood. We hypothesized that lack of Lhx8 perturbs global expression of genes preferentially expressed in oocytes. We compared Lhx8 knockout and wild type ovaries using Affymetrix 430 2.0 microarray platform.
Keywords: Genetic Modification
 
Overall design Each array was hybridized with cRNA produced from pooled total RNA from at least 25 specimens. The experiment was performed with 3 replicates. The results from these three arrays was compared to arrays hybridized with cRNA produced from pooled total RNA from at least 25 wild type specimens of the same genetic background.
 
Contributor(s) Rajkovic A, Choi Y, Ballow D, Xin A
Citation(s) 18509161
Submission date May 10, 2007
Last update date Feb 11, 2019
Contact name Aleksandar Rajkovic
E-mail(s) rajkovic@bcm.edu
Organization name Baylor College of Medicine
Street address One Baylor Plaza
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (5)
GSM178084 Newborn Mouse Ovary_LHX8 Null_1
GSM178085 Newborn Mouse Ovary_LHX8 Null_2
GSM178086 Newborn Mouse Ovary_LHX8 Null_3
This SubSeries is part of SuperSeries:
GSE11897 Lim Homeobox Gene, LHX8, Is Essential for Mouse Oocyte Differentiation and Survival
Relations
BioProject PRJNA109017

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE7774_RAW.tar 25.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
Raw data provided as supplementary file

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