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| Status |
Public on Oct 31, 2007 |
| Title |
Transcriptional changes in Lhx8 Null newborn mouse ovaries |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Lhx8 is a homeobox gene expressed in oocytes and critical in oogenesis. Lhx8 deficiency leads to rapid loss of postnatal oocytes. Early oocyte differentiation is poorly understood. We hypothesized that lack of Lhx8 perturbs global expression of genes preferentially expressed in oocytes. We compared Lhx8 knockout and wild type ovaries using Affymetrix 430 2.0 microarray platform.
Keywords: Genetic Modification
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| Overall design |
Each array was hybridized with cRNA produced from pooled total RNA from at least 25 specimens. The experiment was performed with 3 replicates. The results from these three arrays was compared to arrays hybridized with cRNA produced from pooled total RNA from at least 25 wild type specimens of the same genetic background.
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| Contributor(s) |
Rajkovic A, Choi Y, Ballow D, Xin A |
| Citation(s) |
18509161 |
| Submission date |
May 10, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Aleksandar Rajkovic |
| E-mail(s) |
rajkovic@bcm.edu
|
| Organization name |
Baylor College of Medicine
|
| Street address |
One Baylor Plaza
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| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (5)
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| This SubSeries is part of SuperSeries: |
| GSE11897 |
Lim Homeobox Gene, LHX8, Is Essential for Mouse Oocyte Differentiation and Survival |
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| Relations |
| BioProject |
PRJNA109017 |
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