|
| Status |
Public on Feb 10, 2016 |
| Title |
Expression data from small intestine crypts of Zfp148gt/+APCMin/+ and Zfp148+/+APCMin/+ mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The transcription factor Zinc finger protein 148 (Zfp148) interacts physically with the tumor suppressor p53, but the siginficance of this interaction is not known. We recently showed that knockout of Zfp148 in mice leads to ectopic activation of p53 in tissues and cultured fibroblasts, suggesting that Zfp148 represses p53 activity.
Here we hypothesized that targeting Zfp148 would unleash p53 activity and protect against cancer development, and test this idea in the APCMin/+ mouse model of intestinal adenomas.
|
| |
|
| Overall design |
Crypt-enriched tissues were isolated by laser microdissection (PALM) from the small intestines (proximal) of Zfp148gt/+APCMin/+ and Zfp148+/+APCMin/+ mice for RNA extraction and hybridization to Affymetrix microarrays.
|
| |
|
| Contributor(s) |
Nilton A, Sayin VI, Lindahl P |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Feb 10, 2016 |
| Last update date |
Feb 21, 2018 |
| Contact name |
Per Lindahl |
| E-mail(s) |
per.lindahl@wlab.gu.se
|
| Phone |
+46 31 3423832
|
| Organization name |
University of Gothenburg
|
| Department |
Institute of Medicine
|
| Lab |
Wallenberg Laboratory
|
| Street address |
Sahlgrenska University Hospital, Bruna Straket 16
|
| City |
Gothenburg |
| ZIP/Postal code |
413 45 |
| Country |
Sweden |
| |
|
| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA311516 |
Less...
More...