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| Status |
Public on Nov 10, 2016 |
| Title |
ALS-causing mutations differentially affect PGC-1alpha expression and function in the brain vs. peripheral tissues |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Amyotrophic later sclerosis is a motor neuron disease accompanied by metabolic changes. PGC (PPAR gamma coactivator)-1alpha is a master regulator of mitochondrial biogenesis and function and of critical importance for all metabolically active tissues. PGC-1alpha is a genetic modifier of ALS.
We used microarray analysis to identify PGC-1alpha target genes in the brain.
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| |
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| Overall design |
Total mRNA from striata of three homozygous B6.129-Ppargc1atm1Brsp/J and three wild type littermates were used for the analysis.
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| Contributor(s) |
Bayer H, Holzmann K, Witting A |
| Citation(s) |
27818323 |
| Submission date |
Feb 15, 2016 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Hanna Bayer |
| Organization name |
Ulm University
|
| Street address |
Helmholtzstrasse 8/1
|
| City |
Ulm |
| ZIP/Postal code |
89081 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA312104 |
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