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| Status |
Public on May 10, 2017 |
| Title |
Effect of human genetic variability on gene transcription in dorsal root ganglia and association with pain phenotypes [transcript-level] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Single nucleotide polymorphisms (SNP) can affect mRNA gene expression, in a tissue-specific manner. In this work we survey association of SNP alleles with mRNA gene expression in human dorsal root ganglions (DRG) to gain insights into pathophysiology of pain phenotypes.
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| Overall design |
DNA and RNA was extracted from dorsal root ganglions of deceased human patients; the DNA used for genotyping and the RNA used for mRNA expression level measurement. Expression quantitative trait loci analyses were performed between SNP alleles and mRNA levels to evaluate strength of association between minor allele content at a given SNP and mRNA level of a given gene/exon.
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| Contributor(s) |
Parisien M, Khoury S, Chabot-Doré A, Slade GD, Smith SB, Fillingim RB, Ohrbach R, Greenspan JD, Maixner W, Belfer I, Mogil JS, Diatchenko L |
| Citation(s) |
28564610, 31199789 |
| Submission date |
Feb 16, 2016 |
| Last update date |
Jul 30, 2019 |
| Contact name |
Marc Parisien |
| E-mail(s) |
marc.parisien@mcgill.ca
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| Organization name |
McGill University
|
| Department |
Dentistry
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| Lab |
Human Pain Genetics Lab
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| Street address |
740 Dr. Penfield Avenue
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| City |
Montreal |
| State/province |
Quebec |
| ZIP/Postal code |
H3A 0G1 |
| Country |
Canada |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (214)
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| This SubSeries is part of SuperSeries: |
| GSE78150 |
Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes |
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| Relations |
| BioProject |
PRJNA312228 |
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