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Series GSE78068 Query DataSets for GSE78068
Status Public on Jul 21, 2016
Title Identification of baseline gene expression signatures predicting therapeutic responses to three biologic agents in rheumatoid arthritis: a retrospective observational study
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The aim of this study was to identify the specific molecular biological features predicting the therapeutic outcomes of three bDMARDs, infliximab (IFX), tocilizumab (TCZ), and abatacept (ABT) by studying blood gene expression signature of patients prior to biologic treatment in a unified test platform. GSEA analyses showed that inflammasome genes were significantly upregulated in IFX’s NON-REM compared with its REM. In TCZ’s REM, B cell-specifically expressed genes were upregulated. RNA elongation, apoptosis-related, and NK cell-specifically expressed genes were upregulated in ABT’s NON-REM.
 
Overall design RA patients who responded inadequately to methotrexate and were later commenced with any one of IFX (n=140), TCZ (n=38), and ABT (n=31) as their first biologic between May 2007 and November 2011 were enrolled. Whole blood gene expression data were obtained prior to their biologic administration. They were defined as remission and non-remission groups, according to CDAI at 6 months of biologic therapy.
 
Contributor(s) Nakamura S, Suzuki K, Iijima H, Hata Y, Lim CR, Ishizawa Y, Kameda H, Amano K, Matsubara K, Matoba R, Takeuchi T
Citation(s) 27435242
Submission date Feb 18, 2016
Last update date Jan 23, 2019
Contact name Seiji Nakamura
E-mail(s) nakamura@dna-chip.co.jp
Phone +81-3-5777-1700
Organization name DNA Chip Research Inc.
Street address 1-15-1, Kaigan, Suzuebaydium 5F
City Minato-ku
State/province Tokyo
ZIP/Postal code 105-0022
Country Japan
 
Platforms (1)
GPL6480 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)
Samples (209)
GSM2065979 Before infliximab administration, Non-remission-1
GSM2065980 Before infliximab administration, Non-remission-2
GSM2065981 Before infliximab administration, Non-remission-3
Relations
BioProject PRJNA312528

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE78068_RAW.tar 1.6 Gb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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