NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE78076 Query DataSets for GSE78076
Status Public on Jul 01, 2016
Title Multi-organ mapping of cancer risk
Organism Mus musculus
Experiment type Expression profiling by array
Summary Cancers are distributed unevenly across the body; but the importance of cell intrinsic factors such as stem cell function in determining organ cancer risk is unknown. Therefore, we used cre-recombination of conditional lineage tracing, oncogene and tumour suppressor alleles to define populations of stem and non-stem cells in mouse organs, and test their life-long susceptibility to tumorigenesis. We show that cancer risk is determined by the life-long generative capacity of mutated cells. This relationship held true in the presence of multiple genotypes and regardless of developmental stage, strongly supporting the notion that stem cells dictate organ cancer risk. Using the liver as a model system, we further show that damage-induced activation of stem cell function markedly increases cancer risk. Therefore, we propose that a combination of stem cell mutagenesis and extrinsic factors that enhance the proliferation of these cell populations, creates a ‘perfect storm’ that ultimately determines organ cancer risk.
 
Overall design Long-term lineage tracing and conditional oncogenic targeting of Prom1-expressing cells in various mouse organs.
 
Contributor(s) Zhu L, Finkelstein D, Gao CL, Shi L, Wang Y, López-Terrada D, Wang KS, Utley S, Pounds SB, Neale G, Ellison DW, Onar-Thomas A, Gilbertson RJ
Citation(s) 27565343
Submission date Feb 18, 2016
Last update date Aug 06, 2018
Contact name David Finkelstein
E-mail(s) david.finkelstein@stjude.org
Phone 9014953931
Organization name St Jude Children's Research Hospital
Department Computational Biology
Street address 332 N. Lauderdale St.
City Memphis
State/province TN
ZIP/Postal code 38105
Country USA
 
Platforms (1)
GPL11180 [HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate
Samples (103)
GSM2066272 bronchopulmonary adenocarcinoma_dissected LQZ131
GSM2066273 bronchopulmonary adenocarcinoma_dissected LQZ501
GSM2066274 gastric adenocarcinoma abdomen metastasis_dissected LQZ046
Relations
BioProject PRJNA312535

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE78076_RAW.tar 210.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap