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Series GSE7809 Query DataSets for GSE7809
Status Public on Nov 29, 2007
Title Transcriptional expression of ICC-DMP and ICC-MY in murine small intestine
Organism Mus musculus
Experiment type Expression profiling by array
Summary Interstitial cells of Cajal (ICC) have important functions in regulation of motor activity in the gastrointestinal tract. In murine small intestine ICC are gathered in the region of the myenteric plexus (ICC-MY) and within the deep-muscular plexus near the submucosal surface of the circular muscle layer (ICC-DMP). These two classes of ICC have different physiological functions.
ICC-MY are pacemaker cells and generate the slow wave electrical rhythmicity of gastrointestinal organs. ICC-DMP form synaptic connections with the varicose nerve terminals of enteric motor neurons and are involved in reception and transduction of motor neurotransmission. In the present study we used recently developed highly selective techniques to isolate the two classes of ICC from enzymatically dispersed intestinal muscles by fluorescence-activated cell sorting. Transcriptional expression of the two functional classes was investigated using DNA microarray analysis.
Keywords: comparative transcriptional profiling
 
Overall design ICC-DMP and ICC-MY cells were isolated from the murine small intestinal tissues and their transcriptional expression was compared with that of the tunica muscularis tissues. Transcriptional expression profiles of ICC-DMP and ICC-MY were compared to each other also.
 
Contributor(s) Chen H, Young DL, Sanders KM
Citation(s) 17895395
Submission date May 15, 2007
Last update date Feb 11, 2019
Contact name Hui Chen
Organization name University of Nevada, Reno
Department Physiology and Cell Biology
Street address 1664 N Virginia St
City Reno
State/province NV
ZIP/Postal code 89557
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (8)
GSM189464 ICC-DMP, biological rep1
GSM189465 ICC-DMP, biological rep2
GSM189466 ICC-DMP, biological rep3
Relations
BioProject PRJNA100029

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Supplementary file Size Download File type/resource
GSE7809_RAW.tar 27.1 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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