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| Status |
Public on Sep 27, 2016 |
| Title |
Investigation of the effect of succinate and dimethyl malonate on murine bone-marrow derived macrophages (BMDMs) treated with or without LPS |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We aim to further elucidate the effect of succinate and the succinate dehydrogenase inhibtor, dimethyl malonate, on macrophages treated with LPS. Specifically we want to deepen our understanding of how these reagents influence both LPS-induced IL-1B and IL-10.
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| Overall design |
BMDMs were either left untreated or treated with succinate or dimethyl malonate for 3 h prior to treatment with or without LPS for 4 or 48 h.
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| Contributor(s) |
Mills E, O'Neill L, Varma M, Li B, Xavier R, Latorre I |
| Citation(s) |
27667687 |
| Submission date |
Mar 02, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Mukund Varma |
| E-mail(s) |
mmv1301@gmail.com
|
| Organization name |
Broad Institute
|
| Street address |
415 Main Street
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02139 |
| Country |
USA |
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| Platforms (1) |
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| Samples (21)
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| Relations |
| BioProject |
PRJNA314136 |
| SRA |
SRP071087 |
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