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| Status |
Public on Aug 23, 2017 |
| Title |
Mouse hepatoblastoma models with expression of mutant β-catenin and/or c-Myc for therapeutic target identification of childhood liver cancer |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Hepatoblastoma (HB), the most common type of pediatric liver cancer, is associated with aberrant wnt/β-catenin activation and Myc amplification/overexpression. Mice expressing both alleles developed HBs and HCCs with incomplete penetrance by 5-6 weeks of age with fetal and mixed fetal/embryonal HBs, the most prevalent histologic HB subtypes seen in children being the predominant tumor types. To address the roles of mutant wnt/β-catenin activation and Myc over-expression in the pathogenesis of HB, c-Myc and mutant dominant-stable β-catenin were co-targeted to immature cells of the developing mouse liver.
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| Overall design |
Whole genome gene expression profiling with Agilent 1 color protocol were performed to total of 11 samples (4 Wild types, 3 with mutant beta-catenin expression, and 4 with c-Myc expression) derived from tumor-bearing livers.
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| Contributor(s) |
Comerford SA, Hinnant EA, Chen Y, Tomlinson GE, Hammer RE |
| Citation(s) |
27734029 |
| Submission date |
Mar 10, 2016 |
| Last update date |
Jun 27, 2018 |
| Contact name |
Yidong Chen |
| E-mail(s) |
cheny8@uthscsa.edu
|
| Phone |
2105629163
|
| Organization name |
UT Health Science Center at San Antonio
|
| Department |
Population Health Sciences
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| Street address |
8403 Floyd Curl Drive, MSC 7784
|
| City |
San Antonio |
| State/province |
Texas |
| ZIP/Postal code |
78229 |
| Country |
USA |
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| Platforms (1) |
| GPL13912 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version) |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA314896 |
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