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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jul 02, 2007 |
| Title |
Protein 4.1B suppresses prostate cancer progression and metastasis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Protein 4.1B is a 4.1/ezrin/radixin/moesin (FERM) domain-containing protein whose expression is frequently lost in a variety of human tumors, including meningiomas, non-small-cell lung cancers and breast carcinomas. However, its potential tumor suppressive function under in vivo conditions remains to be validated. In a screen for genes involved with prostate cancer metastasis, we found that 4.1B expression is reduced in highly metastatic tumors. Downregulation of 4.1B increased the metastatic propensity of poorly metastatic cells in an orthotopic model of prostate cancer. Furthermore, 4.1B-deficient mice displayed increased susceptibility for developing aggressive, spontaneous prostate carcinomas. In both cases, enhanced tumor malignancy was associated with reduced apoptosis. As expression of Protein 4.1B is frequently downregulated in human clinical prostate cancer, as well as in a spectrum of other tumor types, these results suggest a more general role for Protein 4.1B as a negative regulator of cancer progression to metastatic disease.
Keywords: disease state
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| Overall design |
primary cell line vs metastasis cell line
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| Contributor(s) |
Wong S, Haack H, Shen SS, Whittaker CA, Hynes RO |
| Citation(s) |
17640904 |
| Submission date |
May 28, 2007 |
| Last update date |
Aug 10, 2018 |
| Contact name |
steve shen |
| E-mail(s) |
ssshen@mit.edu
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| Organization name |
MIT
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| Street address |
77 mass ave
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| City |
cambridge |
| State/province |
MA |
| ZIP/Postal code |
02139 |
| Country |
USA |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (6)
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| GSM155023 |
Prostate subcutaneous tumors #78 derived from human PC-3 cells, biological rep1 |
| GSM155024 |
Prostate subcutaneous tumors #78 derived from human PC-3 cells, biological rep2 |
| GSM155025 |
Prostate subcutaneous tumors #78 derived from human PC-3 cells, biological rep3 |
| GSM155026 |
Prostate subcutaneous tumors #82 derived from human PC-3 cells, biological rep1 |
| GSM155027 |
Prostate subcutaneous tumors #82 derived from human PC-3 cells, biological rep2 |
| GSM155028 |
Prostate subcutaneous tumors #82 derived from human PC-3 cells, biological rep3 |
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| Relations |
| BioProject |
PRJNA100091 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE7930_RAW.tar |
21.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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