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| Status |
Public on May 18, 2016 |
| Title |
Memory CD8+ T cells require stress-levels of acetate for optimal function |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
How systemic metabolic alterations during acute infections impact immune-cell function remains poorly understood. Hess and colleagues demonstrate that acetate rapidly increases during infections, which drives acetylation of GAPDH in memory CD8+ T cells and thereby catalyzes the rapid recall response.
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| Overall design |
Comparison of mRNA profile of control vs. 3d acetate exposed memory OT-I T cells
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| Contributor(s) |
Balmer ML, Ma EH, Bantug GR, Grählert J, Pfister S, Glatter T, Jauch A, Dimeloe S, Slack E, Dehio P, Krzyzaniak MA, King CG, Burgener A, Fischer M, Develioglu L, Belle R, Recher M, Bonilla WV, Pinschewer DD, Macpherson AJ, Hapfelmeier S, Jones RG, Hess C |
| Citation(s) |
27212436 |
| Submission date |
Mar 25, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Christoph Hess |
| E-mail(s) |
chess@uhbs.ch
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| Organization name |
University Basel
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| Department |
Department of Biomedicine
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| Lab |
Immunobiology
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| Street address |
Hebelstrasse 20
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| City |
Basel |
| ZIP/Postal code |
4031 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA316377 |
| SRA |
SRP072343 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE79600_RAW.tar |
610.0 Kb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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