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Series GSE80119 Query DataSets for GSE80119
Status Public on Jul 01, 2016
Title Effects of exendin-4 in Brunner's glands of male GLP-1R-/- and wild-type control mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary To gain insight into the biological functions of the highly expressed GLP-1R in Brunner’s glands, transcriptome analyses were conducted in male GLP-1R-/- and wild-type control mice. Analyses were performed 6 hours after a single s.c. dose of exendin-4 (1.0mg/kg s.c.), following 18 hours of two doses of exendin-4 (1.0 mg/kg s.c., administered at 0 and 9 hours), and in untreated controls. Brunner’s glands were isolated by laser capture micro dissection and extracted total RNA was used for microarray profiling.
Overall design A total of 18 samples consisting of laser captured microdissected Brunner's glands from individual male GLP-1R-/- and wild-type (CD-1) mice. Before the isolation of Brunner's glands, mice were dosed with exendin-4 for 6 and 18 hours. The extracted total RNA from Brunner's glands were compared by full transcriptome profiling.
Contributor(s) Frederiksen KS, Søkilde R, Bang-Berthelsen CH, Folkersen L
Citation(s) 27542128
Submission date Apr 11, 2016
Last update date Sep 30, 2016
Contact name Klaus Stensgaard Frederiksen
Organization name Novo Nordisk A/S
Department Molecular Genetics
Street address Novo Nordisk Park F9.1.07
City Måløv
ZIP/Postal code DK-2760
Country Denmark
Platforms (1)
GPL20766 [Mouse4302_Mm_ENSG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [CDF: Mouse4302_Mm_ENSG_17.0.0]
Samples (18)
GSM2113013 wt_untreated_1
GSM2113014 wt_exendin (18h)_10
GSM2113015 wt_exendin (18h)_11
BioProject PRJNA317983

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Supplementary file Size Download File type/resource
GSE80119_RAW.tar 80.7 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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