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| Status |
Public on Jun 19, 2016 |
| Title |
Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We used RNA sequencing to compare the expression profile of 8 CD11b+ human glioblastoma-associated microglia/monocytes (hGAMs) samples to 8 human non-tumor CD11b+ microglia samples. Hierarchical clustering and principal component analysis showed a clear separation of the two sample groups and we identified 334 significantly regulated genes in hGAMs. In comparison to human control microglia hGAMs up-regulate genes associated with mitotic cell cycle, cell migration, cell adhesion, and extracellular matrix organization.
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| Overall design |
Comparison of the mRNA expression profile of 8 CD11b+ human glioblastoma-associated microglia/monocytes samples and 8 human non-tumor CD11b+ microglia samples (isolated form postmortem and epilepsy tissues).
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| Contributor(s) |
Szulzewsky F, Arora S |
| Citation(s) |
27312099 |
| BioProject |
PRJNA315145 |
| Submission date |
Apr 15, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Sonali Arora |
| E-mail(s) |
sarora@fredhutch.org
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| Organization name |
FHCRC
|
| Street address |
1100 Fairview Ave N,
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| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109 |
| Country |
USA |
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| Platforms (1) |
| GPL18460 |
Illumina HiSeq 1500 (Homo sapiens) |
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| Samples (16)
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| Relations |
| SRA |
SRP071750 |
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