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| Status |
Public on Nov 12, 2016 |
| Title |
Transcriptional profiling of CD4+ T cells activated in murine malaria. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
CD4+ T cells are critical for defense against the Plasmodium parasites that cause malaria. To better understand CD4+ T cell effector mechanisms during malaria, we performed microarray analysis of CD4+ T cells from naïve and infected mice.
Comparison of activated (CD44 hi CD62L lo) CD4+ T cells from infected mice to bulk CD4+ T cells from naïve mice revealed a subset of genes that were upregulated by infection with Plasmodium chabaudi. These results help generate a more complete picture of CD4+ T cell function in malaria.
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| Overall design |
Total CD4+ T cells were double-sorted from the blood of adult naïve female mice; activated (CD44 hi CD62L lo) CD4+ T cells were double-sorted from the blood of adult female mice 6 d post-infection with P. chabaudi. Four independent biological replicates were performed per condition.
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| Contributor(s) |
Kim CC, Fontana MF |
| Citation(s) |
27923070 |
| Submission date |
May 06, 2016 |
| Last update date |
Oct 02, 2019 |
| Contact name |
Charlie Kim |
| E-mail(s) |
cckim47@gmail.com
|
| Organization name |
University of California, San Francisco
|
| Department |
Medicine
|
| Lab |
Kim
|
| Street address |
1001 Potrero Ave
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94110 |
| Country |
USA |
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| Platforms (1) |
| GPL13912 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version) |
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| Samples (7)
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| Relations |
| BioProject |
PRJNA320886 |
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