|
| Status |
Public on May 12, 2017 |
| Title |
Donor T cells in ovarian graft versus host disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of donor CD4+ and CD8+ T cells purified from spleens and ovaries after murine syngeneic and allogeneic hematopoietic stem cell transplantation
Infertility associated with ovarian failure is a serious late complication for female survivors of allogeneic hematopoietic stem cell transplantation (SCT). While the role of pretransplant conditioning regimen has been well appreciated, increasing application of reduced-intensity conditioning facilitated us to revisit the other factors possibly affecting ovarian function after allogeneic SCT. We have addressed whether donor T-cell mediated graft-versus-host disease (GVHD) could be causally related to female infertility in mice. To study transcriptomes of donor T cells infiltrating into the ovary, donor T cells were sorted from recipients' ovaries and microarray analysis was performed.
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| Overall design |
Syngeneic splenic CD4+ T cells (n=2), Syngeneic splenic CD8+ T cells (n=3), Allogeneic splenic CD4+ T cells (n=2), Allogeneic splenic CD8+ T cells (n=3), Allogeneic ovarian CD4+ T cells (n=2), Allogeneic ovarian CD8+ T cells (n=4)
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| Contributor(s) |
Hashimoto D, Teshima T, Miyawaki K |
| Citation(s) |
27903524 |
| Submission date |
May 12, 2016 |
| Last update date |
Feb 02, 2018 |
| Contact name |
Daigo Hashimoto |
| Organization name |
Hokkaido University
|
| Department |
Department of Hematology
|
| Street address |
N15W7 Kita-ku
|
| City |
Sapporo |
| State/province |
Hokkaido |
| ZIP/Postal code |
0608638 |
| Country |
Japan |
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| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
|
| Samples (16)
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| Relations |
| BioProject |
PRJNA321441 |
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