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| Status |
Public on May 26, 2016 |
| Title |
caArray_lavar-00111: SPECIFIC GENE EXPRESSION PROFILES ASSOCIATED WITH INFANT DISSEMINATED NEUROBLASTOMA |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Neuroblastoma (NB) tumours have the highest incidence of spontaneous remission, especially among the stage 4s NB subgroup affecting infants. Clinical distinction of stage 4s from lethal stage 4 can be difficult, but critical for therapeutic decisions. The aim of this study was to investigate differential gene expression amongst infant disseminated NB subgroups. Thirty-five NB tumours from patients diagnosed at < 18 months (25 stage 4 and 10 stage 4s), were evaluated gene expression analyses. Initial comparison analyses between stage 4s and 4 < 12 months tumours revealed distinct gene expression profiles. A significant portion of genes mapped to chromosome 1 (p<0.0001), 90% with higher expression in stage 4s, and chromosome 11 (p=0.0054), 91% with higher expression in stage 4. Less definite expression profiles were observed between stage 4s and 4 < 18m, yet, association with chromosomes 1 (p<0.0001) and 11 (p=0.005) was maintained. Distinct gene expression profiles but no significant association with specific chromosomal region localization was observed between stage 4s and stage 4 < 18 months without MYCN amplification. Distinct gene expression profiles characterize spontaneously regressing or aggressive infant NB, providing the biological basis for the distinct clinical behaviour.
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| Overall design |
lavar-00111
Assay Type: Gene Expression
Provider: Affymetrix
Array Designs: HG_U95Av2
Organism: Homo sapiens (ncbitax)
Tissue Sites: Adrenal Gland
Material Types: synthetic_RNA, total_RNA
Cell Types: primary tumor
Disease States: Neuroblastoma
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| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 25, 2016 |
| Last update date |
Dec 13, 2018 |
| Contact name |
Mervi Heiskanen |
| E-mail(s) |
mervi.heiskanen@nih.gov
|
| Phone |
2402765175
|
| Organization name |
NCI
|
| Department |
CBIIT
|
| Street address |
9609 Medical Center Drive, 1W378
|
| City |
Rockville |
| State/province |
MD |
| ZIP/Postal code |
20850 |
| Country |
USA |
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| Platforms (1) |
| GPL8300 |
[HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array |
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| Samples (27)
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| Relations |
| BioProject |
PRJNA323356 |
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