|
| Status |
Public on Aug 02, 2016 |
| Title |
Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The Hippo pathway is an important regulator of organ size and tumorigenesis. It is unclear, however, how Hippo signaling provides the cellular building blocks required for rapid growth. Here, we report that transgenic zebrafish expressing an activated form of the Hippo pathway effector Yap1 develop enlarged livers and are prone to liver tumor formation. Transcriptomic profiling reveals that Yap1 reprograms genes involved in glutamine metabolism.
|
| |
|
| Overall design |
Analysis of gene expression in WT and lf:Yap transgenic zebrafish livers.
|
| |
|
| Contributor(s) |
Cox A, Goessling W |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jun 03, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Andrew Cox |
| Organization name |
Harvard Medical School
|
| Department |
Brigham and Women's Hospital
|
| Lab |
Goessling Laboratory
|
| Street address |
77 Avenue Louis Pasteur
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL14875 |
Illumina HiSeq 2000 (Danio rerio) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA324425 |
| SRA |
SRP076112 |
Less...
More...