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Series GSE8239 Query DataSets for GSE8239
Status Public on May 29, 2008
Title Interlocking transcriptomics, proteomics and toponomics technologies for brain tissue analysis in murine hippocampus
Organism Mus musculus
Experiment type Expression profiling by array
Summary We have correlated transciptomics, proteomics and toponomics analyses of hippocampus tissue of inbred C57/BL6 mice to analyse the interrelationship of expressed genes and proteins at different levels of organization. We find that transcriptome and proteome levels of function are highly conserved between different mice, while the topological organization (the toponome) of protein clusters in synapses of the hippocampus is highly individual, with only few interindividual overlaps (0.15 %). In striking contrast, the overall spatial patterns of individual synaptic states, defined by protein clusters, have boundaries within a strict and non-individual spatial frame of the total synaptic network. The findings are the first to provide insight in the systems biology of gene expression on transcriptome, proteome and toponome levels of function in the same brain subregion. The approach may lay the ground for designing studies of neurodegeneration in mouse models and human brains.
Keywords: brain proteome, transcriptome, toponome, synapses
 
Overall design 4 biological replicates, all wild type
 
Contributor(s) Bode M, Irmler M, Friedenberger M, May C, Jung K, Stephan C, Meyer HE, Lach C, Hillert R, Krusche A, Beckers J, Marcus K, Schubert W
Citation(s) 18283665
Submission date Jun 22, 2007
Last update date Feb 11, 2019
Contact name Johannes Beckers
E-mail(s) beckers@helmholtz-muenchen.de
Organization name Helmholtz Zentrum Muenchen
Department Institute of Experimental Genetics
Street address Ingolstaedter Landstr. 1
City Neuherberg
ZIP/Postal code 85764
Country Germany
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (4)
GSM203973 Hippocampus wt sample 11
GSM203974 Hippocampus wt sample 13
GSM203975 Hippocampus wt sample 15
Relations
BioProject PRJNA101177

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE8239_RAW.tar 13.3 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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