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| Status |
Public on Aug 29, 2017 |
| Title |
Transcription profile of WT and LKB1 (encoded by the gene Stk11)-deficient Treg cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
LKB1 deficiency in Treg cells impairs their survival, metabolism and suppressive function. To exclude the impact of excessive inflammation on LKB1-deficient Treg cells, we generated mixed bone marrow (BM) chimeras using Foxp3-Cre WT and Foxp3-Cre Stk11 fl/fl BM cells, together with CD45.1+ BM cells.
We used microarray to compare the global transcription profile of dornor-derived LKB1-deficient Tregs with WT counterparts.
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| |
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| Overall design |
In total 10 samples; 5 sampels WT Treg cells and 5 samples of LKB1-deficient Treg cells
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| |
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| Contributor(s) |
Yang K, Bastardo Blanco D, Shrestha S, Neale G, Chi H |
| Citation(s) |
28847007 |
| Submission date |
Jun 07, 2016 |
| Last update date |
Feb 21, 2018 |
| Contact name |
Geoffrey Neale |
| E-mail(s) |
geoffrey.neale@stjude.org
|
| Organization name |
St Jude Childrens Research Hospital
|
| Department |
Hartwell Center
|
| Street address |
262 Danny Thomas Place
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (10)
|
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| Relations |
| BioProject |
PRJNA324713 |
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