|
| Status |
Public on Dec 23, 2007 |
| Title |
integrin alpha7 overexpression effects on skeletal muscle transcriptions |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of integrin alpha7 transgenic mice skeletal muscle transcription profiles comparing to wild type controls. Integrin alpha7 is the major laminin binding integrin in muscle cells. Enhancing its expression has been demonstrated to alleviate pathology in a murine model of Duchenne muscular dystrophy. Results of this study provide insights into the effects of increasing integrin alpha7 expression on skeletal muscle transcription and physiology in vivo. This analysis also evaluates any potential possible side effects associate with enhancing integrin alpha7 in skeletal muscle.
Keywords: transgenic mice comparision to wild type controls
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| |
|
| Overall design |
Equal amount of total RNA from six animals of each genotype were pooled to generate a biological replicate. Total of three biological replicates were used. Together, 18 mice of each genotype were used in this analysis.
|
| |
|
| Contributor(s) |
Liu j, Kaufman SJ |
| Citation(s) |
18045857 |
| Submission date |
Jun 27, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Jianming Liu |
| E-mail(s) |
liu10@uiuc.edu
|
| Phone |
217-333-6058
|
| Fax |
(217) 244-1648
|
| Organization name |
University of Illinois at urbana-champaign
|
| Department |
Department of Cell and Developmental Biology
|
| Lab |
Dr. Stephen J. Kaufman
|
| Street address |
B107 CLSL, 601 S. Goodwin Avenue
|
| City |
Urbana |
| State/province |
IL |
| ZIP/Postal code |
61801 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (6)
|
| GSM206048 |
Integrin alpha7 transgenic mouse rep1 |
| GSM206052 |
Integrin alpha7 transgenic mouse rep2 |
| GSM206053 |
Integrin alpha7 transgenic mouse rep3 |
|
| Relations |
| BioProject |
PRJNA101289 |
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