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Series GSE8313 Query DataSets for GSE8313
Status Public on Dec 23, 2007
Title integrin alpha7 overexpression effects on skeletal muscle transcriptions
Organism Mus musculus
Experiment type Expression profiling by array
Summary Analysis of integrin alpha7 transgenic mice skeletal muscle transcription profiles comparing to wild type controls. Integrin alpha7 is the major laminin binding integrin in muscle cells. Enhancing its expression has been demonstrated to alleviate pathology in a murine model of Duchenne muscular dystrophy. Results of this study provide insights into the effects of increasing integrin alpha7 expression on skeletal muscle transcription and physiology in vivo. This analysis also evaluates any potential possible side effects associate with enhancing integrin alpha7 in skeletal muscle.
Keywords: transgenic mice comparision to wild type controls
 
Overall design Equal amount of total RNA from six animals of each genotype were pooled to generate a biological replicate. Total of three biological replicates were used. Together, 18 mice of each genotype were used in this analysis.
 
Contributor(s) Liu j, Kaufman SJ
Citation(s) 18045857
Submission date Jun 27, 2007
Last update date Feb 11, 2019
Contact name Jianming Liu
E-mail(s) liu10@uiuc.edu
Phone 217-333-6058
Fax (217) 244-1648
Organization name University of Illinois at urbana-champaign
Department Department of Cell and Developmental Biology
Lab Dr. Stephen J. Kaufman
Street address B107 CLSL, 601 S. Goodwin Avenue
City Urbana
State/province IL
ZIP/Postal code 61801
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM206030 Intronic WT control rep1
GSM206033 Intronic WT control rep2
GSM206037 Intronic WT control rep3
Relations
BioProject PRJNA101289

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE8313_RAW.tar 51.7 Mb (http)(custom) TAR (of CEL, CHP, EXP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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