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| Status |
Public on Jan 31, 2017 |
| Title |
Schistosomula exposed to HDAC inhibitor (Trichostatin A) [12hrs] |
| Organism |
Schistosoma mansoni |
| Experiment type |
Expression profiling by array
|
| Summary |
HDACs inhibitors induces mortality in the parasite Schistosoma mansoni (schistosomula and adult worms), and became an interesting drug class for the development of new drugs to treat schistosomiasis. In order to understand the effect of histone hyperacetylation on the parasite, we tested the effect of the HDAC inhibitor Trichostatin A on schistosomula gene expression.
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| Overall design |
Newly transformed schistosomula were exposed to 1 µM Trichostatin A or vehicle solution (ethanol) and kept in culture for 12 h. Three independent biological replicates were assayed for each condition.
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| Contributor(s) |
Anderson L, Verjovski-Almeida S |
| Citation(s) |
28406899 |
| Submission date |
Jun 09, 2016 |
| Last update date |
May 02, 2017 |
| Contact name |
Leticia Anderson |
| E-mail(s) |
leticianderson@gmail.com
|
| Phone |
+55-11-26273853
|
| Organization name |
Instituto Butantan
|
| Department |
Parasitologia
|
| Lab |
Laboratório de Expressão Gênica em Eucariotos
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| Street address |
Av. Vital Brasil, 1500
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| City |
São Paulo |
| State/province |
SP |
| ZIP/Postal code |
05503-900 |
| Country |
Brazil |
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| Platforms (1) |
| GPL22001 |
Agilent-033004 USP Schistosoma mansoni 4x180K microarray |
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| Samples (6)
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| GSM2196150 |
Schistosomula 1 µM TSA 12h replicate 1 |
| GSM2196151 |
Schistosomula 1 µM TSA 12h replicate 1 swap |
| GSM2196152 |
Schistosomula 1 µM TSA 12h replicate 2 |
| GSM2196153 |
Schistosomula 1 µM TSA 12h replicate 2 swap |
| GSM2196154 |
Schistosomula 1 µM TSA 12h replicate 3 |
| GSM2196155 |
Schistosomula 1 µM TSA 12h replicate 3 swap |
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| This SubSeries is part of SuperSeries: |
| GSE83211 |
Schistosomula exposed to HDAC inhibitor (Trichostatin A) |
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| Relations |
| BioProject |
PRJNA325345 |
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