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| Status |
Public on Mar 06, 2017 |
| Title |
Identification of transcriptional changes upon genetic deletion of Vhl, Pbrm1 and double deletion of both Vhl and Pbrm1 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To determine why double deficiency of Vhl and Pbrm1 but not single deficiency of either gene resulted in ccRCC, we performed gene expression profiling of RNA isolated from renal cortices of 3-month-old WT, VhlF/FKsp-Cre, Pbrm1F/FKsp-Cre, and VhlF/FPbrm1F/FKsp-Cre mice.
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| Overall design |
The transcripts from WT, VhlF/FKsp, Pbrm1F/FKsp, VhlF/FPbrm1F/FKsp-Cre 3 month old animals were compared to identify the initial transcriptional events that may be important in ccRCC tumor formation
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| Contributor(s) |
Nargund AM, Hsieh JJ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jun 22, 2016 |
| Last update date |
Feb 21, 2018 |
| Contact name |
Jeffrey Zhao |
| Organization name |
Memorial Sloan Kettering Cancer Center
|
| Department |
Genomics Core
|
| Street address |
1275 York Avenue
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
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| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE83689 |
Vhl and Pbrm1 double deletion effect on kidney |
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| Relations |
| BioProject |
PRJNA326457 |
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