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| Status |
Public on Sep 09, 2016 |
| Title |
Gene expression profiling of neutrophils and whole lung tissue from wildtype and Nrf2 null (Nfe2l2-/-) mice during S. pneumoniae pneumonia [neutrophils] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The transcription factor Nrf2 (gene symbol Nfe2l2) regulates the transcriptional response to oxidative stress and plays a critical protective role in the lungs.
These studies tested the role of Nrf2 during pneumonia induced by Streptococcus pneumoniae (SP) at 24 hours in mice and identified Nrf2-dependent genes and pathways in lung tissue and in recruited neutrophils.
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| Overall design |
Lung neutrophils were isolated from wildtype (WT) and Nrf2 null mice 24 hours after intratracheal instillation of Streptococcus pneumoniae (SP) or an equivalent volume of phosphate-buffered saline (PBS). Gene expression was profiled using Affymetrix Mouse Gene 2.1 ST arrays (Santa Clara, CA, USA).
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| Contributor(s) |
Gomez JC, Dang H, Doerschuk CM |
| Citation(s) |
27566827 |
| Submission date |
Jun 22, 2016 |
| Last update date |
Nov 04, 2018 |
| Contact name |
Claire M. Doerschuk |
| Organization name |
University of North Carolina at Chapel Hill
|
| Department |
Marsico Lung Institute
|
| Street address |
Marsico Hall 7205 CB#7248
|
| City |
Chapel Hill |
| State/province |
NC |
| ZIP/Postal code |
27599-7248 |
| Country |
USA |
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| Platforms (1) |
| GPL22070 |
[MoGene-2_1-st] Affymetrix Mouse Gene 2.1 ST Array [transcript-level na35ens81] |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE83615 |
Gene expression profiling of neutrophils and whole lung tissue from wildtype and Nrf2 null (Nfe2l2-/-) mice during S. pneumoniae pneumonia |
|
| Relations |
| BioProject |
PRJNA326565 |
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