|
| Status |
Public on Jul 08, 2016 |
| Title |
Gene expression profile of HGPS skin fibroblasts upon treatment with JH4 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To gain further insight into the biological effects of JH4, we investigated its impact on gene expression profiles.
We defined a set of genes such as IL33, BRCA1, BLM, Rad51, IL6, IL8, and TNFSF18 whose expression is restored by JH4 treatment
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| |
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| Overall design |
4 total RNA samples from HGPS, JH4-treated HGPS, young (9-yr; N9) and old (81-yr; N81) fibroblasts are anlayzed. Young fibroblast (9-yr) was used control
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| |
|
| Contributor(s) |
Lee S, Oh A |
| Citation(s) |
27617860 |
| Submission date |
Jul 07, 2016 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Bum-Joon Park |
| E-mail(s) |
bjpark1219@pusan.ac.kr
|
| Phone |
82-51-510-2220
|
| Organization name |
Pusan National University
|
| Department |
Molecular Biology
|
| Lab |
Lab of Cancer Research
|
| Street address |
Busandaehak-ro 63
|
| City |
BUSAN |
| ZIP/Postal code |
609-735 |
| Country |
South Korea |
| |
|
| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (4)
|
| GSM2227745 |
Human nomal fibroblast_untreated_9 yr |
| GSM2227746 |
Human nomal fibroblas_untreated_81 yr |
| GSM2227747 |
Human fibroblast cells from HGPS patients_DMSO |
| GSM2227748 |
Human fibroblast cells from HGPS patients_JH4 |
|
| Relations |
| BioProject |
PRJNA328147 |
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