|
| Status |
Public on Jan 01, 2017 |
| Title |
NorUrsodeoxycholic Acid Ameliorates Cholemic Nephropathy in Common Bile Duct Ligated Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Cholestasis may cause cholemic nephropathy that can be modelled in common bile duct ligated (CBDL) mice. We aimed to explore the therapeutic efficacy and mechanisms of norursodeoxycholic acid (norUDCA) in cholemic nephropathy. To determine whether norUrsodeoxycholic acid (norUDCA) prevents cholemic nephropathy in long-term CBDL mice, a norUDCA-enriched diet (0.125% w/v, corresponding to 200 mg/kg/day for a mouse of 25 g body weight eating about 4g daily) or a standard mouse diet (Sniff, Soest, Germany) were started 5 days prior to CBDL and were continued until harvesting 3 weeks thereafter. For transcriptional profiling using microarray technology, we compared sham-operated (SOP) mice and 3-week CBDL mice that were either fed 0.125% norUDCA-enriched or standard mouse diets.
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| Overall design |
We analyzed 3 samples per experimental group (SOP, 3w CBDL, 3w CBDL/norUDCA)
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| Contributor(s) |
Krones E, Fickert P |
| Citation(s) |
28242240 |
| Submission date |
Jul 19, 2016 |
| Last update date |
Feb 21, 2018 |
| Contact name |
Karin Wagner |
| E-mail(s) |
kar.wagner@medunigraz.at
|
| Organization name |
Medical University Graz
|
| Department |
Molecular Biology
|
| Street address |
Stiftingtalstrasse 24
|
| City |
Graz |
| State/province |
Styria |
| ZIP/Postal code |
8010 |
| Country |
Austria |
| |
|
| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (9)
|
| GSM2242181 |
Kidney_3w_CommonBileDuctLigation_164 |
| GSM2242182 |
Kidney_3w_CommonBileDuctLigation_165 |
| GSM2242183 |
Kidney_3w_CommonBileDuctLigation_170 |
| GSM2242184 |
Kidney_5dnorUDCAPrefeeding_3w_CommonBileDuctLigation_172 |
| GSM2242185 |
Kidney_5dnorUDCAPrefeeding_3w_CommonBileDuctLigation_175 |
| GSM2242186 |
Kidney_5dnorUDCAPrefeeding_3w_CommonBileDuctLigation_179 |
|
| Relations |
| BioProject |
PRJNA330394 |
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