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Series GSE84654 Query DataSets for GSE84654
Status Public on Mar 08, 2018
Title Comprehensive lncRNAs expression profiling reveals the potential role of lncRNAs in systemic lupus erythematosus [Human LncRNA Array v3.0]
Organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary long non-coding RNAs (lncRNAs) are novel non-coding RNAs which play an important part in regulating gene transcription and translation, modulating protein function, and acting as competing endogeneous RNA. Moveover, there is increasing evidence showing that aberrant expressions of lncRNAs are implicated in various cancers. Yet, their roles in systemic lupus erythematosus (SLE), a prototypical autoimmune disease, remain unknown. To reveal the implications of LncRNAs in SLE, we used Human LncRNA Array v3.0 microarrays to measure the expression profiles of lncRNAs in T cells of patients with SLE and healthy controls. we found 869 upregulated lncRNAs and 1066 downregulated lncRNAs in SLE patients compared with controls. Coding-non-coding gene coexpression (CNC) network was constructed based on the correlation analysis between the differentially expressed lncRNA and mRNA. Downregulation of two lncRNAs, uc001ykl.1 and ENST00000448942 was established using Real-time quantitative PCR. These results showed abrrant expression profiles of lncRNAs in T cells of SLE patients and revealed their potential role in SLE.
 
Overall design In this study, we determined expression profile of lncRNAs in T cells of six SLE patients (S5, S9, S11, S15, S18, S25) and three healthy controls (C1, C2, C3) using Human LncRNA Array v3.0 microarray.
 
Contributor(s) Li L, Ye D
Citation(s) 28622785
Submission date Jul 21, 2016
Last update date Mar 12, 2018
Contact name Lian-Ju Li
Organization name Anhui Medical University
Department Department of Epidemiology and Biostatistics, School of Public Health
Street address 81 Meishan Road
City Hefei
State/province Anhui
ZIP/Postal code 230032
Country China
 
Platforms (1)
GPL16956 Agilent-045997 Arraystar human lncRNA microarray V3 (Probe Name Version)
Samples (9)
GSM2247223 T_SLE_S5 [Human LncRNA Array v3.0]
GSM2247224 T_SLE_S9 [Human LncRNA Array v3.0]
GSM2247225 T_SLE_S11 [Human LncRNA Array v3.0]
This SubSeries is part of SuperSeries:
GSE84656 Comprehensive expression profiling reveals the potential role of lncRNAs and circRNAs in systemic lupus erythematosus
Relations
BioProject PRJNA330778

Download family Format
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MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE84654_RAW.tar 24.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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