 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on May 05, 2017 |
| Title |
Expression data from human primary skeletal muscle myotubes treated with aldosterone alone or co-incubated with aldosterone plus spironolactone, eplerenone, or mifepristone |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To uncover whether aldosterone induces gene expression changes through mineralocorticoid or glucocorticoid receptors and determine if eplerenone and spironolactone could block aldosterone induced gene expression to the same extent
|
| |
|
| Overall design |
12 total samples were analyzed. 3 biological replicates for each of the following treatment groups were included: 1) aldosterone; 2) spironolactone plus aldosterone; 3) eplerenone plus aldosterone; 4) mifepristone plus aldosterone. Pairwise comparison between groups were carried out and a fold-change ≥2 were selected.
|
| |
|
| Contributor(s) |
Rafael-Fortney JA, Chadwick JA |
| Citation(s) |
28432191 |
| Submission date |
Jul 29, 2016 |
| Last update date |
Oct 29, 2018 |
| Contact name |
Jill Rafael-Fortney |
| E-mail(s) |
rafael-fortney.1@osu.edu
|
| Organization name |
The Ohio State University
|
| Department |
Physiology & Cell Biology
|
| Lab |
410 Hamilton Hall
|
| Street address |
1645 Neil Ave
|
| City |
Columbus |
| State/province |
OH |
| ZIP/Postal code |
43210 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
|
| Samples (12)
|
| GSM2255622 |
human myotubes, aldosterone treated, biological rep 1a |
| GSM2255623 |
human myotubes, aldosterone treated, biological rep 2a |
| GSM2255624 |
human myotubes, aldosterone treated, biological rep 3a |
| GSM2255625 |
human myotubes, spironolactone plus aldosterone treated, biological rep 1 |
| GSM2255626 |
human myotubes, spironolactone plus aldosterone treated, biological rep 2 |
| GSM2255627 |
human myotubes, spironolactone plus aldosterone treated, biological rep 3 |
| GSM2255628 |
human myotubes, eplerenone plus aldosterone treated, biological rep 1 |
| GSM2255629 |
human myotubes, eplerenone plus aldosterone treated, biological rep 2 |
| GSM2255630 |
human myotubes, eplerenone plus aldosterone treated, biological rep 3 |
| GSM2255631 |
human myotubes, mifepristone plus aldosterone treated, biological rep 1 |
| GSM2255632 |
human myotubes, mifepristone plus aldosterone treated, biological rep 2 |
| GSM2255633 |
human myotubes, mifepristone plus aldosterone treated, biological rep 3 |
|
| This SubSeries is part of SuperSeries: |
| GSE84992 |
Expression data from human primary skeletal muscle myotubes treated with aldosterone alone or in combination |
|
| Relations |
| BioProject |
PRJNA335845 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE84991_RAW.tar |
288.4 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...