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Series GSE8507 Query DataSets for GSE8507
Status Public on Sep 18, 2007
Title Neutrophil and PBMC gene expression data from Job's Syndrome
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Hyper IgE Recurrent Infection Syndrome (HIES or Job’s syndrome), is a rare disorder of immunity and connective tissue, typically manifest with boils, cyst-forming pneumonias, and extremely elevated serum IgE as well as retained primary dentition and bone abnormalities. Inheritance can be autosomal dominant.
In order to identify a specific defect or gene of interest, we performed microarray expression analysis on samples from patients with Job's syndrome and from healthy control subjects.
Keywords: time course
 
Overall design Polymorphonuclear leukocytes (PMNs) and peripheral blood mononuclear cells (PBMCs) were isolated from whole blood from patients with Job's syndrome and healthy control subjects. PMNs and PBMCs were incubated with or without IgG- and C3bi-coated latex beads for 3 and 6 hours.
 
Contributor(s) Holland SM, DeLeo FR, Hsu AP, Elloumi HZ, Uzel G, Brodsky N, Freeman AF, Demidowich A, Davis J, Turner ML, Malech HL, Gallin JI, Kobayashi SD, Whitney AR, Voyich JM, Musser J, Woellner C, Schaffer AA, Puck JM, Grimbacher B
Citation(s) 17881745
Submission date Jul 17, 2007
Last update date Mar 25, 2019
Contact name Addie Whitney
E-mail(s) awhitney@niaid.nih.gov
Organization name NIH/NIAID/RML
Department LHBP
Lab DeLeo
Street address 903 S 4th St
City Hamilton
State/province MT
ZIP/Postal code 59840
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (141)
GSM211011 PMN_control_0min_Patient1
GSM211012 PMN_control_0min_Patient2
GSM211013 PMN_control_0min_Patient3
Relations
BioProject PRJNA101619

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE8507_RAW.tar 746.2 Mb (http)(custom) TAR (of CEL, CHP)
Processed data provided as supplementary file
Processed data included within Sample table

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