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Series GSE85222

Query DataSets for GSE85222

Status

Public on Aug 16, 2016

Title

Effects of Oltipraz on Gene Expression in the Livers of Wild-Type and Nrf2-null Mice

Organism

Mus musculus

Experiment type

Expression profiling by array

Summary

Oltipraz is an activator of Nrf2 but is also an activator of other pathways including those mediated by constitutive activated receptor (CAR). To identify genes regulated by oltipraz that were Nrf2-dependent, we compared gene expression after exposure in wild-type and Nrf2-null mice.

Overall design

Wild-type or Nrf2-null mice were treated each day for 4 days with 75 mg/kg/day/day oltipraz in corn oil or corn oil alone. There were 4 biological replicates used for each of the 4 genotype-treatment groups. Gene expression in the livers of the mice was evaluated using Affymetrix mouse exon arrays (MoEx-1_0-st-v1).

Contributor(s)

Corton C

Citation(s)

30114225

Submission date

Aug 04, 2016

Last update date

Sep 06, 2018

Contact name

Christopher Corton

E-mail(s)

corton.chris@epa.gov

Organization name

US-EPA

Lab

MD B105-01

Street address

109 TW Alexander Dr.

City

Research Triangle Park

State/province

ZIP/Postal code

27711

Country

USA

Platforms (1)

GPL6096

[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [transcript (gene) version]

Samples (16)

More...

GSM2262363	Liver_ vehicle control_4day_KO_biological_rep 1
GSM2262364	Liver_ vehicle control_4day_KO_biological_rep 2
GSM2262365	Liver_ vehicle control_4day_KO_biological_rep 3

Relations

BioProject

PRJNA336576

Download family	Format
SOFT formatted family file(s)	SOFT
MINiML formatted family file(s)	MINiML
Series Matrix File(s)	TXT

Supplementary file	Size	Download	File type/resource
GSE85222_RAW.tar	336.6 Mb	(http)(custom)	TAR (of CEL, TXT)
Processed data included within Sample table
Processed data provided as supplementary file