 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Mar 20, 2018 |
| Title |
Expression data of intact and ventilated wildtype and Zmpste24-deficient mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To study how changes in the nuclear mechanical properties may modify the development of Ventilator-induced lung injury, mice of both genotypes were studied at baseline or after 2.5 hours of mechanical ventilation (PIP 15cmH2O, ZEEP, 100 breaths/min, inspiratory:expiratory ratio 1:1, inpired oxygen fraction 0.21).After that, mice were sacrificed, the lungs estracted and gene expression measured in order to identify the differential gene expression depending on the different nuclear stifness.
|
| |
|
| Overall design |
12 samples were analyzed. 6 from Zmpste24-deficient mice where 3 were baseline and 3 were submitted to mechanical ventilation and 6 wiltype where 3 were baseline and 3 were submitted to mechanical ventilation.
|
| |
|
| Contributor(s) |
Alonso IL, Prieto JB, Albaiceta GM, Rodríguez LA |
| Citation(s) |
30158154 |
| Submission date |
Aug 05, 2016 |
| Last update date |
Aug 31, 2018 |
| Contact name |
Guillermo M Albaiceta |
| E-mail(s) |
gma@crit-lab.org
|
| Phone |
+34 985 652433
|
| Organization name |
Instituto de Investigación Sanitaria del Principado de Asturias
|
| Lab |
Laboratorio de Investigación Traslacional en el paciente crítico
|
| Street address |
Avenida de Roma s/n
|
| City |
Oviedo |
| ZIP/Postal code |
33011 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (12)
|
| GSM2263555 |
lung intact wildtype mouse, biological rep.1 |
| GSM2263556 |
lung intact wildtype mouse, biological rep.2 |
| GSM2263557 |
lung intact wildtype mouse, biological rep.3 |
| GSM2263558 |
lung intact zmpste24-deficient mouse, biological rep.1 |
| GSM2263559 |
lung intact zmpste24-deficient mouse, biological rep.2 |
| GSM2263560 |
lung intact zmpste24-deficient mouse, biological rep.3 |
| GSM2263561 |
lung ventilated wildtype mouse, biological rep.1 |
| GSM2263562 |
lung ventilated wildtype mouse, biological rep.2 |
| GSM2263563 |
lung ventilated wildtype mouse, biological rep.3 |
| GSM2263564 |
lung ventilated zmpste24-deficient mouse, biological rep.1 |
| GSM2263565 |
lung ventilated zmpste24-deficient mouse, biological rep.2 |
| GSM2263566 |
lung ventilated zmpste24-deficient mouse, biological rep.3 |
|
| Relations |
| BioProject |
PRJNA337978 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE85269_RAW.tar |
112.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...