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Status |
Public on Mar 20, 2018 |
Title |
Expression data of intact and ventilated wildtype and Zmpste24-deficient mice |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
To study how changes in the nuclear mechanical properties may modify the development of Ventilator-induced lung injury, mice of both genotypes were studied at baseline or after 2.5 hours of mechanical ventilation (PIP 15cmH2O, ZEEP, 100 breaths/min, inspiratory:expiratory ratio 1:1, inpired oxygen fraction 0.21).After that, mice were sacrificed, the lungs estracted and gene expression measured in order to identify the differential gene expression depending on the different nuclear stifness.
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Overall design |
12 samples were analyzed. 6 from Zmpste24-deficient mice where 3 were baseline and 3 were submitted to mechanical ventilation and 6 wiltype where 3 were baseline and 3 were submitted to mechanical ventilation.
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Contributor(s) |
Alonso IL, Prieto JB, Albaiceta GM, Rodríguez LA |
Citation(s) |
30158154 |
Submission date |
Aug 05, 2016 |
Last update date |
Aug 31, 2018 |
Contact name |
Guillermo M Albaiceta |
E-mail(s) |
gma@crit-lab.org
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Phone |
+34 985 652433
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Organization name |
Instituto de Investigación Sanitaria del Principado de Asturias
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Lab |
Laboratorio de Investigación Traslacional en el paciente crítico
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Street address |
Avenida de Roma s/n
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City |
Oviedo |
ZIP/Postal code |
33011 |
Country |
Spain |
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Platforms (1) |
GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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Samples (12)
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GSM2263555 |
lung intact wildtype mouse, biological rep.1 |
GSM2263556 |
lung intact wildtype mouse, biological rep.2 |
GSM2263557 |
lung intact wildtype mouse, biological rep.3 |
GSM2263558 |
lung intact zmpste24-deficient mouse, biological rep.1 |
GSM2263559 |
lung intact zmpste24-deficient mouse, biological rep.2 |
GSM2263560 |
lung intact zmpste24-deficient mouse, biological rep.3 |
GSM2263561 |
lung ventilated wildtype mouse, biological rep.1 |
GSM2263562 |
lung ventilated wildtype mouse, biological rep.2 |
GSM2263563 |
lung ventilated wildtype mouse, biological rep.3 |
GSM2263564 |
lung ventilated zmpste24-deficient mouse, biological rep.1 |
GSM2263565 |
lung ventilated zmpste24-deficient mouse, biological rep.2 |
GSM2263566 |
lung ventilated zmpste24-deficient mouse, biological rep.3 |
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Relations |
BioProject |
PRJNA337978 |
Supplementary file |
Size |
Download |
File type/resource |
GSE85269_RAW.tar |
112.6 Mb |
(http)(custom) |
TAR (of CEL) |
Processed data included within Sample table |
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