NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE85350 Query DataSets for GSE85350
Status Public on Mar 03, 2017
Title Bisphenol A alternatives can effectively substitute for estradiol in promoting cell growth through estrogen receptor alpha in human breast cancer cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Plasticizers with estrogenic activity, such as bisphenol A (BPA), have been reported to have potential adverse health effects in humans, especially in fetal and infant stages. Due to mounting evidence and public pressure BPA is being phased out by the plastics manufacturing industry and is being replaced by other bisphenol variants in “BPA-free” products. We have compared estrogenic activity of 7 bisphenol analogues (BPA; bisphenol S, BPS; bisphenol F, BPF; bisphenol AP, BPAP; bisphenol AF, BPAF; bisphenol Z, BPZ; bisphenol B, BPB) in human breast cancer cell lines.
We used microarrays to detail the alterations in gene expression profiles associated with MCF-7 cell line exposure to bisphenol A analogues
 
Overall design MCF-7 cells treated during a period of 48h with the BPA alternatives and the natural hormone 17β-estradiol were subjected to a full transcriptome profiling using the Affymetrix microarray platform.
 
Contributor(s) Mesnage R, Arno MJ
Citation(s) 28591870
Submission date Aug 09, 2016
Last update date May 23, 2019
Contact name Robin Mesnage
E-mail(s) robinmes@gmail.com
Phone +447482206767
Organization name Kings College London
Street address Guy's Hospital, 8th Floor, Tower Wing
City London
ZIP/Postal code SE1 9RT
Country United Kingdom
 
Platforms (1)
GPL17586 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
Samples (33)
GSM2265483 MCF-7_BPAF_rep1
GSM2265484 MCF-7_BPAF_rep2
GSM2265485 MCF-7_BPAF_rep3
Relations
BioProject PRJNA338240

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE85350_RAW.tar 677.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap