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| Status |
Public on Aug 06, 2019 |
| Title |
Inhibition of Tumor Growth and Metastasis by EMMPRIN Multiple Antigenic Peptide (MAP) Vaccination Is Mediated by Immune Modulation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report here that a EMMPRINs-specific cancer peptide vaccination, where the peptide was modified and synthesied as a multiple antigenic peptide (MAP), significantly inhibited tumor growth and metastases. Specifically, we describe changes in the gene expression profile as assessed by RNAseq in tumors derived from mice implanted with the colon tumorigenic carcinoma (CT26 cells), and vaccinated with either a control scrambled multiple antigenic peptide (Scr-MAP) or with an epitope-specific EMMPRIN multiple antigenic peptide (designated 161-MAP).
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| |
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| Overall design |
Toral RNA from tumors from 3 mice in each group (Scr-MAP and 161-MAP vaccinated) were extracted, and RNAseq analysis revealed differentially expressed genes (DEGs).
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| Contributor(s) |
Rahat MA |
| Citation(s) |
28197388 |
| Submission date |
Aug 10, 2016 |
| Last update date |
Aug 06, 2019 |
| Contact name |
Michal (Miki) A. Rahat |
| Organization name |
Carmel Medical Center & Technion-Israel Institute of Technology
|
| Department |
Immunology, Faculty of Medicine
|
| Lab |
Immunotherapy Lab
|
| Street address |
7 Michal st.,
|
| City |
Haifa |
| ZIP/Postal code |
3436212 |
| Country |
Israel |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA338459 |
| SRA |
SRP081234 |
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