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| Status |
Public on Jul 26, 2007 |
| Title |
Expression data from transgenic mice (3 mo) inducibly expressing human alpha1-antitrypsin in the liver |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
In the classical form of α1antitrypsin deficiency a mutant protein accumulates in a polymerized form in the ER of liver cells causing liver damage and carcinogenesis by a gain-of-toxic function mechanism. Recent studies have indicated that the accumulation of mutant α1antitrypsin Z in the ER specifically activates the autophagic response but not the unfolded protein response and that autophagy plays a critical role in disposal of insoluble α1antitrypsin Z. In this study, we used genomic analysis of the liver in a novel transgenic mouse model with inducible expression to screen for changes in gene expression that would potentially define how the liver responds to accumulation of this mutant protein.
Keywords: genomic analysis, alpha1-antitrypsin deficiency, comparative study, adult animals, inducible expression, liver specific
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| Overall design |
Liver RNA from adult (3 mo old) male mice inducibly expressing human alpha1-antitrypsin wild type (M) or mutant (Z) form exclusively in the liver was subjected to genomic analysis. Groups: mutant AAT (Z), wild type AAT (M), expressing (4), non-expressing (1), wild type littermates (WT); 3 biological replicates/each group
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| Contributor(s) |
Hidvegi T, Ewing M, Mirnics K |
| Citation(s) |
17635928 |
| Submission date |
Jul 26, 2007 |
| Last update date |
Jan 08, 2019 |
| Contact name |
Tunda Hidvegi |
| Organization name |
University of Pittsburgh
|
| Street address |
3460 Fifth Ave
|
| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15213 |
| Country |
USA |
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| Platforms (1) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA101761 |
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