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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Apr 27, 2017 |
| Title |
Identification of extensive cellular diversity and maturation of active neuronal networks in long-term cultures of human brain organoids |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We analyzed gene expression in over 80,000 individual cells isolated from 31 human whole-brain organoids that has developed for 3-6 months. We find that organoids can generate a broad diversity of cells, which we show are related to known endogenous classes, including subpopulations of neurons and progenitors of the cerebral cortex
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| Overall design |
Single cell Droplet sequencing of human cerebral organoid
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| Contributor(s) |
Quadrato G, Nguyen T, Macosko EZ, Sherwood JL, Berger D, Maria N, Scholvin J, Goldman M, Kinney J, Boyden E, Lichtman J, Williams ZM, McCarroll SA, Arlotta P |
| Citation(s) |
28445462 |
| Submission date |
Aug 28, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Paola Arlotta |
| Organization name |
Harvard University
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| Department |
Stem Cell & Regenerative Biology
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| Street address |
7 Divinity Avenue
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| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02138 |
| Country |
USA |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA340373 |
| SRA |
SRP083140 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE86153_RAW.tar |
899.8 Mb |
(http)(custom) |
TAR (of CSV) |
| GSE86153_organoid_names.txt.gz |
289 b |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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