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| Status |
Public on Mar 10, 2017 |
| Title |
Expression data from E12 mouse lumbar motor neuron subsets |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Sonic hedgehog (Shh) signals via Gli transcription factors to direct digit number and identity in the vertebrate limb. We have characterized the Gli-dependent cis-regulatory network through a combination of whole genome ChIP-on-chip and transcriptional profiling of the developing mouse limb.
In this dataset, we include the expression data obtained from dissected mouse forelimbs using a variety of gain- and loss-of-function hedgehog pathway mutants, as well as limbs dissected into responsive (posterior 2/3ds) and non-responsive (anterior 1/3d) Hh tissues. These data are used to obtain 753 genes that are differentially expressed in response to Shh signaling.
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| Overall design |
6 Total samples were analyzed. We generated the following pairwise comparisons using PowerExpress: medial MN vs lateral MN FDR ≤ x % and a fold-change ≥1.5 were selected.
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| Contributor(s) |
Haase G, Gentien D, de la Grange P |
| Citation(s) |
28270618 |
| Submission date |
Sep 06, 2016 |
| Last update date |
Mar 06, 2018 |
| Contact name |
Pierre de la Grange |
| E-mail(s) |
pierre.delagrange@genosplice.com
|
| Organization name |
GenoSplice technology
|
| Department |
Paris Biotech Santé
|
| Street address |
29, rue du Faubourg Saint-Jacques
|
| City |
Paris |
| ZIP/Postal code |
75014 |
| Country |
France |
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| Platforms (1) |
| GPL6096 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA342022 |
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