 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Jan 11, 2008 |
| Title |
Gene expression in 3T3-L1 mouse tissue (preadipocytes) treated with Trans-10,Cis-12 conjugated linoleic acid(t10c12 CLA) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse white adipose tissue (WAT) and 3T3-L1 adipocyte tissue culture; however in preadipocyte tissue (this series) the UPS/ISR and fat loss is not detected. The early transcriptome changes in 3T3-L1 preadipocyte tissue culture were analyzed using high-density microarrays to better characterize the signaling pathways responding to t10c12 CLA. Their gene expression responses between 4 to 12 hr after treatment do not show a set of genes indicative of an integrated stress response (ISR).
Keywords: control/treatment time course
|
| |
|
| Overall design |
Mouse 3T3-L1 RNA for each time point was isolated from two control (LA) and two treatment (CLA) samples for analysis on four microarrays.
|
| |
|
| Contributor(s) |
LaRosa C, Riethoven JM, Chen H, Xia Y, Zhou Y, Chen M, Miner J, Fromm ME |
| Citation(s) |
17878318 |
| Submission date |
Aug 03, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Jean-Jack M. Riethoven |
| E-mail(s) |
jeanjack@unl.edu
|
| Organization name |
University of Nebraska-Lincoln
|
| Department |
Beadle Center for Biotechnology
|
| Lab |
Bioinformatics Core Research Facility
|
| Street address |
1901 Vine Street
|
| City |
Lincoln |
| State/province |
NE |
| ZIP/Postal code |
68588-0665 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (11)
|
| GSM215299 |
3T3-L1 preadipocyte tissue culture, LA treated, T1, biological rep1 |
| GSM215300 |
3T3-L1 preadipocyte tissue culture, CLA treated, T1, biological rep1 |
| GSM215301 |
3T3-L1 preadipocyte tissue culture, CLA treated, T1, biological rep2 |
| GSM215302 |
3T3-L1 preadipocyte tissue culture, LA treated, T2, biological rep1 |
| GSM215303 |
3T3-L1 preadipocyte tissue culture, LA treated, T2, biological rep2 |
| GSM215304 |
3T3-L1 preadipocyte tissue culture, CLA treated, T2, biological rep1 |
| GSM215305 |
3T3-L1 preadipocyte tissue culture, CLA treated, T2, biological rep2 |
| GSM215306 |
3T3-L1 preadipocyte tissue culture, LA treated, T3, biological rep1 |
| GSM215307 |
3T3-L1 preadipocyte tissue culture, LA treated, T3, biological rep2 |
| GSM215308 |
3T3-L1 preadipocyte tissue culture, CLA treated, T3, biological rep1 |
| GSM215309 |
3T3-L1 preadipocyte tissue culture, CLA treated, T3, biological rep2 |
|
| This SubSeries is part of SuperSeries: |
| GSE11384 |
Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes |
|
| Relations |
| BioProject |
PRJNA109037 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE8683_12hr_RosettaResolver_processed_ratio.xls |
3.0 Mb |
(ftp)(http) |
XLS |
| GSE8683_4hr_RosettaResolver_processed_ratio.xls |
3.0 Mb |
(ftp)(http) |
XLS |
| GSE8683_8hr_RosettaResolver_processed_ratio.xls |
3.0 Mb |
(ftp)(http) |
XLS |
| GSE8683_RAW.tar |
38.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...