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Series GSE8683 Query DataSets for GSE8683
Status Public on Jan 11, 2008
Title Gene expression in 3T3-L1 mouse tissue (preadipocytes) treated with Trans-10,Cis-12 conjugated linoleic acid(t10c12 CLA)
Organism Mus musculus
Experiment type Expression profiling by array
Summary Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse white adipose tissue (WAT) and 3T3-L1 adipocyte tissue culture; however in preadipocyte tissue (this series) the UPS/ISR and fat loss is not detected. The early transcriptome changes in 3T3-L1 preadipocyte tissue culture were analyzed using high-density microarrays to better characterize the signaling pathways responding to t10c12 CLA. Their gene expression responses between 4 to 12 hr after treatment do not show a set of genes indicative of an integrated stress response (ISR).
Keywords: control/treatment time course
Overall design Mouse 3T3-L1 RNA for each time point was isolated from two control (LA) and two treatment (CLA) samples for analysis on four microarrays.
Contributor(s) LaRosa C, Riethoven JM, Chen H, Xia Y, Zhou Y, Chen M, Miner J, Fromm ME
Citation(s) 17878318
Submission date Aug 03, 2007
Last update date Feb 11, 2019
Contact name Jean-Jack M. Riethoven
Organization name University of Nebraska-Lincoln
Department Beadle Center for Biotechnology
Lab Bioinformatics Core Research Facility
Street address 1901 Vine Street
City Lincoln
State/province NE
ZIP/Postal code 68588-0665
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (11)
GSM215299 3T3-L1 preadipocyte tissue culture, LA treated, T1, biological rep1
GSM215300 3T3-L1 preadipocyte tissue culture, CLA treated, T1, biological rep1
GSM215301 3T3-L1 preadipocyte tissue culture, CLA treated, T1, biological rep2
This SubSeries is part of SuperSeries:
GSE11384 Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes
BioProject PRJNA109037

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE8683_12hr_RosettaResolver_processed_ratio.xls 3.0 Mb (ftp)(http) XLS
GSE8683_4hr_RosettaResolver_processed_ratio.xls 3.0 Mb (ftp)(http) XLS
GSE8683_8hr_RosettaResolver_processed_ratio.xls 3.0 Mb (ftp)(http) XLS
GSE8683_RAW.tar 38.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
Processed data are available on Series record
Raw data provided as supplementary file

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